Particularly, between the marginal main effect SNP pairs, highly significant SNP–SNP interactions were identified, which explained a relatively high variance at the P-tau level.
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Genome-Wide Epistasis Study of Cerebrospinal Fluid Hyperphosphorylated Tau in ADNI Cohort.
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The sentences
To be specfic, epistasis leads to complex phenotypic effects, in which the effect of one locus is masked by the effects on another locus or the joint effects of two SNPs may be significant whereas they are ineffective separately [ 13 , 14 ].