Spatially Resolved Proteomic and Transcriptomic Profiling of Anaplastic Lymphoma Kinase-Rearranged Pulmonary Adenocarcinomas Reveals Key Players in Inter- and Intratumoral Heterogeneity.

Homogeneously Expressed Proteins and Genes within the Tumors and Associated Pathways Proteins with a stable expression (i.e., had a low CV) within minimum four tumors ( Section 4 ) ( n = 49) showed marginally significant (one-sided Fisher’s exact test, adj. p < 0.25) enrichment for signaling processes such as PI3K–AKT–mTOR signaling, EPH–ephrin signaling, oncogenic MAPK signaling and signaling by Rho GTPases ( Figure 3 a, Table S5 ).

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