Among five studies that found a decreasing trend in MCC, Chavan et al . attributed it to active degranulation of the mast cells causing continuous histamine release in the early stages leading to the scarcity of mast cells in the more advanced stage of the disease ( 19 ).
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Mast cell expression in oral submucous fibrosis: A systematic review and metanalysis.
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The sentences
Further, the correlation between intact and degranulated mast cells was highly significant ( 20 ).