Store-Operated Calcium Entry Inhibition and Plasma Membrane Calcium Pump Upregulation Contribute to the Maintenance of Resting Cytosolic Calcium Concentration in A1-like Astrocytes.

Although under normal conditions, astrocytes are less likely to be significant generators of Aβ because neurons express higher levels of BACE1 than astrocytes [ 42 , 43 ], it should be noted that astrocytes outnumber neurons over five-fold in the brain [ 44 , 45 ].

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