The top ten modulated biological processes were a cellular response to the virus, positive regulation of the apoptotic process, defence response to the virus, inflammatory response, cellular response to cadmium ion, positive regulation of I-kappaB kinase/NF-kappaB signalling, cellular response to lipopolysaccharide, positive regulation of gene expression, cellular response to tumour necrosis factor, and positive regulation of transcription from the RNA polymerase II promoter, of which the cellular response to the virus was a highly significant (3.06018540743041E-10) biological process modulated via the regulation of eight different genes: CXCL10, IL6, CHUK, IRF3, IFNA1, IFNB1, MIR21, and MAPK14 ( Table 1 ).
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System Biology Approach to Identify the Hub Genes and Pathways Associated with Human H5N1 Infection.
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