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Factors That Influence Sustained Release from Hot-Melt Extrudates.

Pharmaceutics · 2023 · PMC10386192 · PMID 37514182

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a slight trendno p-value reported
Although visually, there was a slight trend for slower release at 100 rpm than at 50 or 75 rpm, an f2 test comparing the dissolution at 75 and 100 rpm resulted in an f2 value of 76 for fraction 2 with a particle size of 800 μm–2 mm and an f2 value of 56 for fraction 6 with particle size 125–250 μm, confirming similarity of the profiles.

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