While stimulation with 50 μg/mL AGE-BSA increased IL-8 gene expression 1.9 times compared to unstimulated samples, this increase failed to reach significance. However, when stimulation with 100 and 200 μg/mL AGE-BSA was compared with stimulation with the same dose control BSA, a significant difference was found between the groups (p = 0.033 and p = 0.006, respectively) ( Figure 3B ).
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Determination of the effects of advanced glycation end products receptor polymorphisms and its activation on structural cell responses and inflammation in asthma.
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