The HSV-1 ICP22 protein selectively impairs histone repositioning upon Pol II transcription downstream of genes.

Nat Commun · 2023 · PMC10390501 · PMID 37524699

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highly significantno p-value reported

Consistent with the metagene analyses, we observed small but highly significant increases in H3, H3K27me3, and H3K36me3 at gene promoters (median log2 fold-changes 0.2, 0.09, 0.06) compared to gene body and downstream regions (Wilcoxon test, p < 10 −10 ).

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