Changing clinical significance of oocyte maturity grades with advancing female age advances precision medicine in IVF.

Since M1 and GV oocytes at our center routinely undergo rescue in-vitro maturation, 1 Table 3 summarizes the procedure’s effectiveness with advancing age based on whether fertilization was normal (defined by the presence of 2 pronuclei 16–18 h after ICSI) or abnormal (presence of no, one, or more than 2 pronuclei): Though GV oocytes especially demonstrated a positive trend with advancing age in percentages of increasingly successful fertilization (p = 0.097), likely due to small numbers, neither group of oocytes reached statistical significance.

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