highly significantp < 0.01
The results showed that the tumor increments in the SPP-treated (780 mm 3 , 664 mm 3 , 407 mm 3 , 243 mm 3 ) and 5-FU groups (153 mm 3 ) were lower than those in the control group (875 mm 3 ), and there was a highly significant difference ( p < 0.01 ).