Heritability in observed and predicted AUDIT-Total and AUDIT-C while moderate (0.0811–0.0843 and 0.0869–0.0816, respectively) are similar and highly significant, while the point estimate for observed AUDIT-P (0.0468) is lower than that in predicted AUDIT-P (0.0769). 3.2.1.1 Genetic correlations Using GCTA and only subjects with measured AUDIT, the r g between the observed and predicted AUDIT-T was 0.863 (se 0.040) in men and 0.884 (se 0.032) in women.
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Missingness adapted group informed clustered (MAGIC)-LASSO: a novel paradigm for phenotype prediction to improve power for genetic loci discovery.
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