There was a decreasing trend in p38 MAP kinase activation (70% decrease at 5 min) and a decrease in COX-2 expression (39% decrease at 6h) with the chelation of extracellular calcium ( Figures 5B, D ) but little effect on p65 and ERK activation ( Figures 5A, C ).
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Prostaglandin F2α requires activation of calcium-dependent signalling to trigger inflammation in human myometrium.
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