Transcription factor expression repertoire basis for epigenetic and transcriptional subtypes of colorectal cancers.

Proc Natl Acad Sci U S A · 2023 · PMC10401032 · PMID 37487069

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0.0800

closest p · 1.6× alpha

0.0800

boldest claim

The sentences

borderline significanceP -value = 0.08so close (0.05 < p ≤ 0.1)

CIMP-H cases with low expression of hypermethylated cCRE-associated TFs, which have better survival, showed a tendency to be enriched for the MSI-H cases with borderline significance ( P -value = 0.08, OR = 2.09) ( Fig. 6 D ).

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an increasing trendno p-value reported

Only H3K9me3-marked regions in the context of CGI showed an increasing trend to be methylated with increasing CIMP phenotype, but this was far less compared to that observed for H3K27me3-marked regions, while the H3K9me3-marked regions associated with non-CGI have a low tendency to be methylated across the CIMP spectrum.

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