highly significantP = 1.5 × 10 -59
These ROS-responsive genes overlapped with 207 ++Fe-induced and 10 ++Fe-suppressed genes, and the degree of overlap between ROS-responsive and ++Fe-inducible genes was highly significant ( P = 1.5 × 10 -59 by Fisher’s exact test), confirming that excess Fe causes oxidative stress in leaves ( Figure 6E ).