Discussion In the BASE-II study of community-dwelling elderly subjects, there was a positive association of SELENOP with hypertension, and a U-shaped association of Se with hypertension, along with a positive trend for an association of SELENOP with T2D, which was restricted to men.
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Sex-specific associations of serum selenium and selenoprotein P with type 2 diabetes mellitus and hypertension in the Berlin Aging Study II.
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In the current study there was an overall trend for a positive association of SELENOP with T2D in men, in agreement with the mechanistic studies for SELENOP and most of the observational human studies [ 22 ].