failed to reach significancep < 0.05
The loss of renal transcriptional identity followed a similar pattern to the chromatin accessibility changes: PAX8 KD alone showed a negative enrichment for the proximal epithelial signature C4 but failed to reach significance (p < 0.05) and P8 1 S1 1/2 (A) showed significant downregulation of the signature which reduced further over time (P8 1 S1 1/2 (LT)) ( Figures 4 B and 4C).