Barely Significant
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Long-term environmental metal exposure is associated with hypomethylation of CpG sites in NFKB1 and other genes related to oncogenesis.

Clin Epigenetics · 2023 · PMC10405444 · PMID 37550793

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highly significantno p-value reported
A highly significant increase in the expression of the IGF2 gene in response to exposure to five heavy metals (Cd, Cr, Cu, Pb and Zn) was reported in fishermen's blood [ 49 ].

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