In cluster A1 (genes with expression levels sharply rising in A‐T cells around passage level 13, Figures 2b and S6 ), a highly significant functional group represented the interferon (IFN) response, with classical IFN‐stimulated genes (ISGs) (e.g., MX1 , IFIT2 , IFIT3 , IFI44 , and TNFAIP3 ) strongly induced (Figures 2c and S7A ; Table S3 ).
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Accelerated replicative senescence of ataxia-telangiectasia skin fibroblasts is retained at physiologic oxygen levels, with unique and common transcriptional patterns.
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