Effects of Buprenorphine/Naloxone and Methadone on Depressive Symptoms in People with Prescription Opioid Use Disorder: A Pragmatic Randomised Controlled Trial.

Can J Psychiatry · 2023 · PMC10411362 · PMID 36519188

Europe PMC DOI

hedged sentence

0.0520

closest p · 1.0× alpha

0.0520

boldest claim

The sentences

borderline significantP = 0.052so close (0.05 < p ≤ 0.1)

The mediated effect was borderline significant between week 12 and week 24 ( P = 0.052), with opioid use accounting for 30.9% of the variance ( P = 0.065).

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