Functional Engagement of the PD-1/PD-L1 Complex But Not PD-L1 Expression Is Highly Predictive of Patient Response to Immunotherapy in Non-Small-Cell Lung Cancer.

However, patients with a high FRET efficiency (Fig 4 B) had considerably better survival (highly significant P < .0001) in first-line treatments compared with low FRET patients (median 50% survival still undefined after 50 months for high FRET v 11 months for low FRET patients).

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