Previous studies have shown that GSEA performed on the upregulated genes in mutant TP53 tumors revealed highly significant enrichment of pathways directly involved in promoting cell cycle progression, including E2F target genes, signatures of G2M checkpoint control, and mitotic spindle [ 16 ].
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Comprehensive Analysis of the Prognostic Significance of the TRIM Family in the Context of TP53 Mutations in Cancers.
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