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From Spike to Symptom: A Contribution to Decoding the Molecular Mechanisms Underlying SARS-CoV-2 Transmission, Infection, and Disease Pathology.

Int J Mol Sci · 2023 · PMC10418666 · PMID 37569670

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extremely significantno p-value reported
This marked the beginning of the COVID-19 pandemic, a global health crisis that has had extremely significant social, economic, and public health implications.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.