Potential Harm of IQOS Smoke to Rat Liver.

Regarding total cholesterol content, no significant differences were found between controls (1.57 ± 0.40 mg g −1 of liver) and treated livers (1.27 ± 0.47 mg g −1 of liver), although a decreasing trend could be seen in those exposed to IQOS.

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With regard to PUFA, an increasing trend was observed in the Δ-desaturase index: both Δ5- and Δ6-desaturases are involved in the formation of n-6 and n-3 long-chain PUFA (LCPUFA), with Δ-6 desaturase being the limiting enzyme in the process.

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