Engineering a Pro-Osteogenic Secretome through the Transient Silencing of the Gene Encoding Secreted Frizzled Related Protein 1.

Int J Mol Sci · 2023 · PMC10419110 · PMID 37569774

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highly significantno p-value reported

In our case, we did not detect a significant reduction of the RANKL/OPG ratio after incubating the osteocytic cell line MLO-A5 with the CM where Sfrp1 was silenced (mCM- Sfrp1 ), but did observe a highly significant reduction of this ratio in the more complex microenvironment of an ex vivo culture of calvaria bone discs, when this has been treated with the mCM- Sfrp1 compared to mCM-Ctrl.

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