NRX-101 (D-cycloserine plus lurasidone) vs. lurasidone for the maintenance of initial stabilization after ketamine in patients with severe bipolar depression with acute suicidal ideation and behavior: a randomized prospective phase 2 trial.

While this trial was underpowered to prove a difference in akathisia between the NRX-101 and lurasidone only groups, a high effect size was seen (d = 1.1) with an increase in akathisia seen in the lurasidone group and a decrease in akathisia seen in the NRX-101 cohort at a trend level of significance (p = 0.14).

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