Oxaliplatin-induced peripheral neurotoxicity in colorectal cancer patients: mechanisms, pharmacokinetics and strategies.

Front Pharmacol · 2023 · PMC10427877 · PMID 37593174

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a positive trendno p-value reported

There is a positive trend towards a higher rate of organ preservation with total neoadjuvant therapy (chemoradiotherapy followed by consolidation chemotherapy, CRT-CNCT) and the watch-and-wait approach compared to induction chemotherapy followed by chemoradiotherapy (INCT-CRT) ( Aref and Abdalla, 2022 ; Garcia-Aguilar et al., 2022 ; Sütcüoğlu et al., 2023 ).

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