Progress in Stem Cells-Based Replacement Therapy for Retinal Pigment Epithelium: In Vitro Differentiation to In Vivo Delivery.

5 Although these initial studies are highly significant, the need to develop a standard cell therapy with features that promote the transplanted tissue to integrate with the host tissue at the transplantation side is essential and requires multi-factorial regenerative, stem cell biology, and tissue engineering approaches. 6 Recent studies suggest that injection of iPSC-derived RPE in the subretinal space leads to improper epithelization of the RPE monolayer.

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