Antinociceptive properties of losmapimod in two acute pain models in rats: behavioural analysis, immunohistochemistry, dose response, and comparison with usual analgesic drugs.

BJA Open · 2022 · PMC10430813 · PMID 37588580

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a decreasing trendno p-value reported

A weaker enhancement of p38 phosphorylation in astrocytes compared with microglial cells has been previously described 8 , 14 , 15 The peak of astrocyte activation or the intensity of losmapimod-induced inhibition possibly occurred before 15 h, and at this time cell activation could be on a decreasing trend.

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