Combination of antidepressants and antipsychotics as a novel treatment option for psychosis in Alzheimer's disease.

Finally, the combination group showed comparable effects with the patients with no drug treatment throughout the 6 years period and demonstrated almost significant beneficial effects in 4, 5, and 6 years of the follow‐up.

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For example, a meta‐analysis consisting of eight randomized, placebo‐controlled studies reported that antidepressant‐antipsychotic co‐treatment was superior to monotherapy with either drug class in the acute treatment of psychotic depression 52 and another study reported that adding SGAs to antidepressants yielded highly significant superiority in treating MDD as well. 53 In that study, Aripiprazole, Olanzapine, Risperidone, and Ziprasidone were found to be more effective than other SGAs. 53 Our study has a few limitations.

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