Genome-wide association studies reveal novel loci associated with pyrethroid and organophosphate resistance in Anopheles gambiae and Anopheles coluzzii.

Curiously, we also found marginally significant signals of association between PM resistance and SNPs in the Vgsc region ( Vgsc –1570Y positively associated in Baguida and Vgsc –995F negatively associated in Korle-Bu).

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In our targeted analyses of SNPs and CNVs in known resistance genes, the number of tests being conducted was considerably smaller and the range of P values that we found to be significant, with the exception of Ace1 , would not come close to significance if FDR control was applied on a genomic scale such as in the GWAS.

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