Post-infection treatment with the E protein inhibitor BIT225 reduces disease severity and increases survival of K18-hACE2 transgenic mice infected with a lethal dose of SARS-CoV-2.

PLoS Pathog · 2023 · PMC10434922 · PMID 37549173

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highly significantno p-value reported

BIT225 treatment showed a highly significant protection from body weight loss and death as compared to vehicle treatment, even when treatment initiation was delayed for 2 days after infection.

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