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Enantioselective organocatalytic synthesis of axially chiral aldehyde-containing styrenes via S<sub>N</sub>Ar reaction-guided dynamic kinetic resolution.

Nat Commun · 2023 · PMC10439945 · PMID 37598233

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an increasing trendno p-value reported
Initially, the ee values of product 3 exhibited an increasing trend, reaching a steady state at 6 hours (95% ee), which might be due to a strong background reaction at the early stage of this transformation.

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