Remote regulation of rs80245547 and rs72673891 mediated by transcription factors C-Jun and CREB1 affect <i>GSTCD</i> expression.

iScience · 2023 · PMC10440715 · PMID 37609638

Europe PMC DOI

hedged sentences

0.0240

closest p · 0.5× alpha

0.0240

boldest claim

The sentences

approximately significantp = 0.024actually significant

Moreover, double mutations at both SNPs (rs72673861G and rs59462153C) consistently showed an approximately significant increase in enhancer activity compared with the GSTCD promoter (p = 0.024), and this increase was mainly influenced by rs72673891G.

also in 27 other papers

highly significantno p-value reported

The genetic signal rs10516526 in the glutathione S-transferase C-terminal domain containing ( GSTCD ) gene is a highly significant and reproducible signal associated with lung function and COPD on chromosome 4q24.

also in 75,794 other papers

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