Sodium pyruvate exerts protective effects against cigarette smoke extract-induced ferroptosis in alveolar and bronchial epithelial cells through the GPX4/Nrf2 axis.

J Inflamm (Lond) · 2023 · PMC10441695 · PMID 37605161

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Different NaPyr concentrations significantly reversed the CSE-mediated effects, with expression levels of ferroptosis-related proteins Nrf2 and GPX4 exhibiting an increasing trend in a NaPyr concentration-dependent manner (Fig. 4 A and B).

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