Biomechanical determinants of endothelial permeability assessed in standard and modified hollow-fibre bioreactors.

Effect of increased viscosity Four hours of pulsatile flow (ASS) with viscosity-increasing xanthan gum (XG) led to an increase in permeability of borderline significance (5.77 ± 0.60 × 10 −6 cm s −1 ; 0.1 > p > 0.05) and 3–5 days of pulsatile flow (CSS) with XG led to a significant decrease in permeability (1.17 ± 0.19 × 10 −6 cm s −1 ; n = 11; p < 0.0001), compared with static conditions with XG (4.43 ± 0.41 × 10 −6 cm s −1 ; n = 7) ( figure 6 ).

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