borderline significantp = 0.047
Although the mean total symptom score was slightly lower in the active arm than the placebo arm from day 7 onwards, this was only borderline significant on day 28 (RD [95% CI] = -0.18 [-0.36; -0.002]; p = 0.047) ( Figure 3 C & Supplementary Table 4 ) and not significant when comparing the percentage of participants with 0, 1, 2, 3, and ≥4 symptoms ( Figure 3 D).