Similar effects are observed in mouse primary cortical neurons ( Figures 3A–C ) and in patient derived SNCA iPSC-derived neurons carrying the PD-associated SNCA triplication ( Figures 3D, E ), although we note that αsyn protein and mRNA level decreases did not quite reach statistical significance in the latter.
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Honokiol decreases alpha-synuclein mRNA levels and reveals novel targets for modulating alpha-synuclein expression.
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