Optimization of a Glucagon-Like Peptide 1 Receptor Antagonist Antibody for Treatment of Hyperinsulinism.

Diabetes · 2023 · PMC10450825 · PMID 37358194

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a decreasing trendno p-value reported

Treatment of WT mice with TB-001-003 or TB-222-023 showed a decreasing trend in plasma insulin levels, a significantly lower insulin to glucose ratio after the second dose of TB-222-023, and no change in β-hydroxybutyrate ( Supplementary Fig. 4 A – C ).

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