The Impact of Muscarinic Antagonism on Psychosis-Relevant Behaviors and Striatal [¹¹C] Raclopride Binding in Tau Mouse Models of Alzheimer's Disease.

Scopolamine increased hopping frequency/distance traveled in P301L/COMTKO mice and htau mice, which is a trend that approached but did not achieve significance in either model ( Figure 1 C t (28) = 1.58, p = 0.06) ( Figure 1 D t (28) = 1.40, p = 0.09), respectively, suggesting that scopolamine treatment may have effectuated a qualitative change in gait from walking and meandering to hopping—a more explosive movement pattern. 3.1.2.

also in 1,397 other papers