Circulating H3K27 Methylated Nucleosome Plasma Concentration: Synergistic Information with Circulating Tumor DNA Molecular Profiling.

All H3K27Me3-, H3K36Me3-, H3K9Me3-, and H3K4Me2-nucleosome levels and the cfDNA concentration showed a weak, but statistically highly significant correlation coefficient with the percentage of MAF ( r = 0.33, 0.31, 0.32, and 0.21, respectively; p -value < 0.0001, and r = 0.28; p -value < 0.001, respectively) ( Figure 2 ).

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