AKT phosphorylation did not show significant deviation from the IGF-only treatment when Mn 2+ was added for 2 or 3 h; while its activity showed an increasing trend, triggered by 200 μM Mn 2+ with IGF for 6 h ( Figure 3 D(ii), N = 3).
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IGF/mTORC1/S6 Signaling Is Potentiated and Prolonged by Acute Loading of Subtoxicological Manganese Ion.
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