Relevance of ATM Status in Driving Sensitivity to DNA Damage Response Inhibitors in Patient-Derived Xenograft Models.

There was a numerical trend for the enrichment of responses in models with low tATM H scores by IHC for AZD6738 monotherapy (38% low vs. 0% high) but no differential for a combination where high tATM models showed >50% TGI responses (63% low vs. 67% high) but with the caveat of a low number of models.

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