Endogenous Galectin-1 Modulates Cell Biological Properties of Immortalized Retinal Pigment Epithelial Cells In Vitro.

After incubation for 72 h, a dose-dependent increase in ARPE-19-LGALS1 −/− cell proliferation was observed, which was most pronounced and highly significant following incubation with 100 ng/mL hr-galectin-1 (83.6 ± 2.3%; p < 0.001) when compared to untreated galectin-1-deficient ARPE-19 cells (65.8 ± 0.8%; Figure 3 B).

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