A Comparative Study on the Lysosomal Cation Channel TMEM175 Using Automated Whole-Cell Patch-Clamp, Lysosomal Patch-Clamp, and Solid Supported Membrane-Based Electrophysiology: Functional Characterization and High-Throughput Screening Assay Development.

Int J Mol Sci · 2023 · PMC10454728 · PMID 37628970

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TMEM175 Tool Compounds Reveal Different Apparent Potencies in HTS Compatible APC and SSME Assays TMEM175 is located in a highly significant risk loci for PD on chromosome 4 [ 53 ] and it was shown recently that TMEM175 deficiency results in unstable lysosomal pH and α-synuclein aggregation, leading to PD pathogenesis [ 5 ].

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