Insights into Sex and Gender Differences in Brain and Psychopathologies Using Big Data.

Male-biased genes were highly enriched for neurological and psychiatric disorders (autism, bipolar disorder, schizophrenia, AD, and Parkinson’s disease), while female-biased genes were barely significant enriched for a few diseases (OCD, AD, schizophrenia, and epilepsy), which suggested that the male-biased genes likely have functional consequences relevant to human brain diseases, consistent with the “female protective model” in neurodevelopmental disorder.

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