marginally non-significantp = 0.053
In the multivariable analysis, a marginally non-significant interaction between the timing of remdesivir administration and baseline disease severity was observed ( p = 0.053, Table S1 ); the early administration of remdesivir in patients with a mild/moderate disease was associated with an indicative (HR: 0.20, 0.03–1.23; p = 0.083) decrease in the hazard of progression to the composite event, whereas there was no statistically significant difference in the patients with a severe disease ( p = 0.393).