Krüppel-like factor 12 regulates aging ovarian granulosa cell apoptosis by repressing SPHK1 transcription and sphingosine-1-phosphate (S1P) production.

J Biol Chem · 2023 · PMC10463260 · PMID 37543362

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a decreasing trendno p-value reported

Indeed, after the overexpression of different concentrations of KLF12 in KGN cells, the SPHK1 concentration showed a decreasing trend at the mRNA/protein level ( Fig. 4 , A and B ).

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