a decreasing trendp < 0.001
coli isolates resistant to most of the antibiotic categories remained stable between 2015 and 2019, though a decreasing trend in the proportion of E. coli isolates resistant to fluoroquinolones (37.8–32.0%, p < 0.001) and aminoglycosides (15.6–11.9%, p = 0.002) was observed over time (Fig. 3 ).