Insertion of an immunodominant T helper cell epitope within the Group A <i>Streptococcus</i> M protein promotes an IFN-γ-dependent shift from a non-protective to a protective immune response.

Although this difference did not quite reach significance (p=0.055), collectively the results indicate that T cell-dependent antibodies contribute to the overall protection induced against GAS-M1 following immunization with GAS-2W.M1. 3.3 The 2W Th cell epitope promotes an enhanced CD4 T cell IFN-γ response in GAS-2W.M1-immunized mice Children are more susceptible to superficial GAS infections than adults and this correlates with reduced IgG3 and IFN-γ production ( 20 ).

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