Socs1-knockout in skin-resident CD4⁺ T cells in a protracted contact-allergic reaction results in an autonomous skin inflammation with features of early-stage mycosis fungoides.

In all cases, a P-value of 0.05 and below was considered significant (*), P < 0.01(**), P < 0.001 (***) and P < 0.0001 as highly significant. 3 Results 3.1 Experimental design We used three groups of transgenic mice with both genders (the gender was not significant in the study) and with age from 7 to 9 weeks: a. an experimental group (n = 9, 4 females, 5 males) with a floxed Socs1 gene deleted through tamoxifen-activated Cre under the

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